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Related Experiment Videos

Gestodene-containing contraceptives

H Kuhl1, C Jung-Hoffmann, I Wiegratz

  • 1Department of Obstetrics and Gynecology, J.W. Goethe University Frankfurt, Germany.

Clinical Obstetrics and Gynecology
|December 1, 1995
PubMed
Summary
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Ginsodes (GSD) in oral contraceptives effectively suppress ovulation and reduce acne due to potent progestogenic and anti-estrogenic effects. While generally safe with good cycle control, they may increase thromboembolic risk in susceptible women.

Area of Science:

  • Pharmacology
  • Endocrinology
  • Gynecology

Background:

  • Ginsodes (GSD) is a potent progestogen used in oral contraceptives.
  • GSD allows for lower doses compared to other progestogens.
  • Its effectiveness stems from high serum concentrations and strong progestogenic/anti-estrogenic activity.

Purpose of the Study:

  • To evaluate the efficacy and safety of monophasic and triphasic oral contraceptives containing GSD.
  • To assess the impact of GSD on hormonal levels, metabolic parameters, and cycle control.
  • To determine the risk of side effects, including thromboembolic events.

Main Methods:

  • Administration of monophasic (30 mcg EE + 75 mcg GSD) and triphasic (30/40/30 mcg EE + 50/70/100 mcg GSD) oral contraceptives.
  • Monitoring of gonadotropin release, ovarian function, and ovulation inhibition.
Keywords:
BiologyBlood Coagulation EffectsCarbohydrate Metabolic EffectsContraceptionContraceptive Agents, Female--pharmacodynamicsContraceptive Agents, Female--side effectsContraceptive Agents, Progestin--pharmacodynamicsContraceptive Agents, Progestin--side effectsContraceptive Agents--pharmacodynamicsContraceptive Agents--side effectsContraceptive EffectivenessContraceptive MethodsEndocrine EffectsEndocrine SystemFamily PlanningGestodene--pharmacodynamicsGestodene--side effectsHematological EffectsHemic SystemLipid Metabolic EffectsLipidsLiterature ReviewMetabolic EffectsOral ContraceptivesPhysiology

Related Experiment Videos

  • Analysis of serum hormone levels (androgens, SHBG), metabolic markers (lipids, glucose), and coagulation parameters.

    • Main Results:

    • Both formulations reliably inhibit ovulation and show good cycle control after initial cycles.
    • Significant reduction in androgens, androgen precursors, and acne incidence observed.
    • Estrogen-dominant hepatic effects noted, with increased triglycerides and VLDL, HDL, and apolipoproteins.
    • Slight, clinically irrelevant impairment of glucose tolerance.
    • Increased pro-coagulatory and fibrinolytic activity, potentially elevating thromboembolic risk in predisposed individuals.

    Conclusions:

    • GSD-containing oral contraceptives are effective for ovulation inhibition and acne reduction.
    • They exhibit favorable metabolic and hormonal profiles with good cycle control.
    • Caution is advised regarding potential increased thromboembolic risk in susceptible women.