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Gabapentin associated with aggressive behavior in pediatric patients with seizures
K B Tallian1, M C Nahata, W Lo
1College of Pharmacy, Division of Neurology, Ohio State University, Columbus, USA.
Epilepsia
|May 1, 1996
Abstract:
Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults. We report 2 children who received GBP for intractable seizures and who developed intolerable aggressive behavior requiring dose reduction or drug discontinuation. Behavioral changes should be recognized as a possible side effect of GBP, especially in mentally retarded children.