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A Protocol for the Production of KLRG1 Tetramer
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Published on: January 13, 2010

A human killer inhibitory receptor specific for HLA-A1,2

C Döhring1, D Scheidegger, J Samaridis

  • 1Basel Institute for Immunology, Switzerland.

Journal of Immunology (Baltimore, Md. : 1950)
|May 1, 1996
PubMed

Killer inhibitory receptors (KIRs) are transmembrane glycoproteins, expressed on NK cells and a small subset of T cells, that inhibit cell-mediated cytotoxicity upon binding to polymorphic MHC class I determinants on target cells. Although human KIRs specific for HLA-C and HLA-B molecules have been characterized, none have been shown to interact with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3.

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