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Related Experiment Videos

Currently practised sterilization methods--some inadvertent consequences

P D Nair1

  • 1Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Thiruvananthapuram, Kerala, India.

Journal of Biomaterials Applications
|October 1, 1995
PubMed
Summary

Common sterilization methods like ethylene oxide, gamma irradiation, and steam can harm polymeric materials, affecting their biocompatibility. This review examines these effects, focusing on steam sterilization

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Area of Science:

  • Materials Science
  • Biocompatibility Studies
  • Sterilization Technologies

Background:

  • Established sterilization methods (ethylene oxide, gamma irradiation, steam) may negatively impact polymeric medical materials.
  • Adverse effects on material properties can compromise device safety and efficacy.
  • Biocompatibility is a critical factor for medical implants and devices.

Purpose of the Study:

  • To review the potential adverse consequences of common sterilization techniques on polymeric materials.
  • To discuss the impact of these sterilization methods on material biocompatibility.
  • To specifically examine the effects of steam sterilization on polyethylene terephthalate (PET).

Main Methods:

  • Literature review of sterilization effects on polymers.

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  • Analysis of changes in material properties post-sterilization.
  • Case study on steam sterilization of polyethylene terephthalate.

    • Main Results:

    • Ethylene oxide, gamma irradiation, and steam sterilization can alter polymer structure and chemistry.
    • These alterations can lead to reduced mechanical strength, degradation, and leaching of harmful substances.
    • Steam sterilization significantly affects the physical and chemical properties of polyethylene terephthalate, impacting its biocompatibility.

    Conclusions:

    • Sterilization processes require careful consideration to maintain polymer integrity and biocompatibility.
    • Material selection and sterilization method must be optimized to prevent adverse effects.
    • Further research is needed to develop sterilization techniques that ensure material safety and efficacy.