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Related Experiment Videos

Lead intoxication in children with pervasive developmental disorders

M Shannon1, J W Graef

  • 1Children's Hospital, Harvard Medical School, The Massachuetts Poison Control System, Boston, MA 02115, USA.

Journal of Toxicology. Clinical Toxicology
|January 1, 1996
PubMed
Summary

Children with pervasive developmental disorders experience later, prolonged lead exposure and higher reexposure rates compared to peers. This highlights the need for vigilant lead intoxication monitoring in this vulnerable population.

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Area of Science:

  • Environmental Health
  • Pediatric Neurology
  • Public Health

Background:

  • Pervasive developmental disorders (PDD) are associated with unique environmental exposures.
  • Lead poisoning in children requires prompt and effective intervention.

Purpose of the Study:

  • To compare lead exposure patterns in children with and without PDD.
  • To investigate reexposure risks in children with PDD and lead intoxication.

Main Methods:

  • Retrospective chart review of children treated in a large, urban lead treatment program.
  • Comparison of 17 children with PDD (including autism) to 30 children without PDD.

Main Results:

  • Children with PDD were older at diagnosis (46.5 vs 30.3 months) and had longer elevated blood lead levels (39.1 vs 14.1 months).

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  • 75% of children with PDD were reexposed to lead, versus 23% of children without PDD, despite interventions.

    • Conclusions:

    • Lead intoxication in children with PDD can occur later in life and has a high reexposure rate.
    • Standard deleaded housing may not prevent reexposure for children with PDD.
    • Continuous monitoring for lead intoxication is crucial for children with developmental delays, extending beyond age three.