Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Three suicide attempts with moclobemide

S Iwersen1, A Schmoldt

  • 1University of Hamburg, Germany.

Journal of Toxicology. Clinical Toxicology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gamma-hydroxybutyrate in urine and serum: additional data supporting current cut-off recommendations.

Forensic science international·2010
Same author

Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective.

Journal of psychopharmacology (Oxford, England)·2006
Same author

Mental disorders in current and former heavy ecstasy (MDMA) users.

Addiction (Abingdon, England)·2005
Same author

[AWMF-guideline: cocaine-, amphetamine-, ecstasy- and hallucinogen-related disorders].

Fortschritte der Neurologie-Psychiatrie·2004
Same author

Rapid and sensitive quantitative analysis of alkyl phosphates in urine after organophosphate poisoning.

Journal of analytical toxicology·2004
Same author

Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics.

Die Pharmazie·2003
Same journal

Ingestion of high-dose buprenorphine by a 4 year-old child.

Journal of toxicology. Clinical toxicology·2005
Same journal

A reassessment of topical organic phosphorus insecticide exposures and permanent paralysis.

Journal of toxicology. Clinical toxicology·2005
Same journal

Methamphetamine toxicity secondary to intravaginal body stuffing.

Journal of toxicology. Clinical toxicology·2005
Same journal

Duodenal perforation after ibuprofen overdose.

Journal of toxicology. Clinical toxicology·2005
Same journal

Delayed dystonia following pimozide overdose in a child.

Journal of toxicology. Clinical toxicology·2005
Same journal

Pattern of acute poisonings in Mashhad, Iran 1993-2000.

Journal of toxicology. Clinical toxicology·2005
See all related articles

Plasma moclobemide levels up to 30 times therapeutic doses were not associated with severe toxicity in overdose cases. Moclobemide appears safer than tricyclic antidepressants in overdose scenarios.

Area of Science:

  • Pharmacology
  • Clinical Toxicology

Background:

  • Assessing the toxicity profile of newer antidepressants like moclobemide is crucial.
  • Understanding overdose effects aids in clinical management and risk assessment.

Observation:

  • Three overdose cases were analyzed: two with moclobemide alone, one with moclobemide and clomipramine.
  • Plasma moclobemide concentrations ranged from 2.8 mg/L to 60.9 mg/L.
  • Patients were monitored for 24 hours post-ingestion.

Findings:

  • High plasma moclobemide levels (10-30 times therapeutic) did not result in serious adverse effects.
  • The combined ingestion case also showed no severe outcomes.
  • Moclobemide demonstrated a considerably lower toxicity profile compared to tricyclic antidepressants.

Related Experiment Videos

Implications:

  • Moclobemide may represent a safer alternative in antidepressant therapy due to its reduced toxicity in overdose.
  • These findings support cautious clinical observation rather than aggressive intervention in moclobemide overdose.
  • Further research into the toxicokinetics and toxicodynamics of moclobemide is warranted.