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Glottal patency during experimental seizures in piglets

T E Terndrup¹, A Kadison, P Woo

¹Department of Emergency Medicine, State University of New York Health Science Center at Syracuse 13210, USA.

Pediatric Research

|December 1, 1995

Summary

During seizures, vocal folds in piglets adduct, narrowing the airway and causing hypoventilation. This vocal fold adduction contributes to increased subglottic resistance during seizures.

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Area of Science:

Respiratory Physiology
Neurology
Otolaryngology

Background:

Airway intact piglets exhibit hypoventilation and increased subglottic resistance during experimental seizures.
Tracheostomized animals show respiratory stimulation, suggesting a role for the upper airway in seizure-induced respiratory changes.

Purpose of the Study:

To investigate the contribution of vocal fold dynamics to increased subglottic resistance during experimental seizures in piglets.

Main Methods:

Anesthetized piglets underwent measurements of subglottic pressure and airflow.
Fiberoptic video endoscopy captured real-time images of vocal fold behavior.
Glottal Area Patency (GAP) was assessed during different respiratory phases (inspiratory onset, peak inspiration, expiratory onset) under baseline, ictal, interictal, and anticonvulsant conditions.

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Main Results:

Vocal folds showed significant reductions in glottal area patency during ictal periods across the respiratory cycle.
Hypoventilation and glottal obstruction during seizures led to decreased pH and PaO2, and increased PaCO2.
Interictal periods were characterized by increased GAP at peak inspiration but reduced GAP at expiratory onset.

Conclusions:

Vocal folds are tonically adducted throughout the respiratory cycle during ictal phases of seizures.
Increased expiratory vocal fold adduction occurs during interictal phases.
Vocal fold dynamics play a crucial role in modulating airway resistance during seizures.