Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin phase advances circadian rhythm

M E Attenburrow1, B A Dowling, P A Sargent

  • 1University Department of Psychiatry, Littlemore Hospital, Oxford, UK.

Psychopharmacology
|October 1, 1995
PubMed
Summary

Subacute melatonin treatment (7 days) advanced the onset of endogenous melatonin secretion in healthy males. A single dose of melatonin had no effect, suggesting its role in organizing human circadian rhythms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastrojejunostomy as a treatment for gastric outflow disorders in four adult horses.

Australian veterinary journal·2023
Same author

No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review.

Acta psychiatrica Scandinavica·2020
Same author

Morphology of the green livers in upstream migrants of Petromyzon marinus L.

Journal of morphology·2018
Same author

The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram.

Progress in neuro-psychopharmacology & biological psychiatry·2018
Same author

How do drugs for psychiatric disorders work?

Epidemiology and psychiatric sciences·2017
Same author

Interferon-α induces negative biases in emotional processing in patients with hepatitis C virus infection: a preliminary study.

Psychological medicine·2017

Area of Science:

  • Chronobiology
  • Endocrinology
  • Sleep Medicine

Background:

  • Melatonin is a hormone crucial for regulating sleep-wake cycles.
  • Understanding melatonin's role in circadian rhythm organization is essential for therapeutic applications.

Purpose of the Study:

  • To investigate the impact of acute and subacute melatonin administration on endogenous melatonin secretion rhythms.
  • To explore melatonin's potential in modulating human circadian timing.

Main Methods:

  • A placebo-controlled, double-blind, cross-over study involving 12 healthy male volunteers.
  • Administration of melatonin (0.5 mg) for 1 day (acute) and 7 days (subacute) at 1700 h.
  • Monitoring endogenous melatonin secretion patterns.

Related Experiment Videos

Main Results:

  • Subacute (7-day) melatonin treatment significantly advanced the onset of endogenous melatonin secretion.
  • Acute (1-day) melatonin administration showed no significant effect on endogenous melatonin secretion onset.
  • The findings support melatonin's role in the organization of human circadian rhythms.

Conclusions:

  • Timed, subacute melatonin administration can effectively advance circadian timing in humans.
  • Melatonin may serve as a tool for managing circadian rhythm disturbances.
  • Further research into melatonin's chronobiotic effects is warranted.