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Detection of liver metastases from colorectal carcinoma: is there a place for routine computed tomography
B van Ooijen1, M Oudkerk, P I Schmitz
1Department of Surgical Oncology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
Background:
A prospective evaluation of the liver by preoperative ultrasonography, conventional computed tomography (CT), and continuous CT angiography (CCTA) was performed in 60 patients with primary or secondary colorectal carcinoma.
Methods:
The standards of reference were palpation of the liver and intraoperative ultrasonography. The imaging techniques were assessed independently of each other.
Results:
In 37 patients 105 liver metastases were identified; 23 patients had no metastases. CCTA and a high sensitivity of 94% (99 lesions identified) in contrast to ultrasonography (48%) and conventional CT (52%). The superiority of CCTA was also manifest in lesions less than 1 cm in diameter. However, the high sensitivity was accompanied by a high false-positive rate, particularly because of variations in the perfusion of normal liver parenchyma. Overall, CCTA had the highest accuracy (74%) compared with ultrasonography and CT (both 57%). The data indicate that preoperative ultrasonography and conventional CT have low sensitivity in the detection of liver metastases.
Conclusions:
Although CCTA seems to be superior to other preoperative imaging techniques, the too low specificity will hamper its routine application in patients with hepatic metastases from colorectal carcinoma.