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Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma
1Department of Neurology, The University of Alabama, Birmingham, 35294-0007, USA.
Annals of Neurology
|May 1, 1996
Abstract:
Hel-N1 and HuD are neuron-specific RNA-binding proteins that are antigenic targets of anti-Hu antibodies. Although expression of Hu antigens is most commonly seen in small-cell lung carcinoma, their exact identity (e.g., Hel-NI, Hel-N2, HuD, and HuC cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinction. Here we demonstrate that Hel-NI and Hel-N2 are expressed in small-cell lung carcinoma using reverse transcription-polymerase chain reaction.