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Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction
A Matsumori1, Y Furukawa, T Hashimoto
1Department of Cardiovascular Medicine, Kyoto University, Japan.
Insights
Serum hepatocyte growth factor (HGF) is a sensitive biomarker for early diagnosis of acute myocardial infarction. Elevated HGF levels were detected within 3 hours of chest pain onset, outperforming creatine kinase.
Area of Science:
- Cardiology
- Biochemistry
- Medical Diagnostics
Background:
- Acute myocardial infarction (AMI) diagnosis relies on timely and accurate biomarkers.
- Early detection of AMI is crucial for effective treatment and improved patient outcomes.
- Existing biomarkers may have limitations in early sensitivity.
Purpose of the Study:
- To evaluate serum hepatocyte growth factor (HGF) as a potential early diagnostic marker for acute myocardial infarction (AMI).
- To compare the diagnostic sensitivity of HGF with creatine kinase in the early stages of AMI.
- To investigate HGF levels in patients with other heart conditions like angina pectoris.
Main Methods:
- Serum samples were collected from patients diagnosed with AMI upon admission.
- Serum HGF levels were measured at various time points after the onset of chest pain.
- Serum creatine kinase levels were also measured for comparison.
- HGF levels in patients with angina pectoris and other heart diseases were assessed.
Main Results:
- Serum HGF was elevated in 80% of AMI patients within 3 hours of chest pain onset (mean 9.4 ng/mL).
- Elevated HGF levels were significantly more frequent than creatine kinase within the first 3 hours.
- HGF levels showed a good correlation with creatine kinase levels at 6-9 hours post-onset.
- No significant increase in serum HGF was observed in patients with angina pectoris or other heart diseases.
Conclusions:
- Serum HGF measurement is a highly sensitive method for the early diagnosis of acute myocardial infarction.
- HGF serves as a valuable biomarker for detecting AMI within hours of symptom onset.
- HGF shows promise as a superior early diagnostic marker compared to traditional biomarkers like creatine kinase.
Abstract:
We measured serum hepatocyte growth factor (HGF) in patients with acute myocardial infarction, angina pectoris, and other heart diseases. In patients with acute myocardial infarction, blood was collected at the time of admission. Serum HGF was elevated within 3 hours in 8 of 10 patients (80%) with acute myocardial infarction after onset of chest pain (9.4 +/- 3.2 ng/mL, mean +/- SEM, values in normal subjects <0.39 ng/mL). Mean value of serum HGF was 11.0 +/-2.6 ng.mL (n=11) in patients who admitted to the hospital between 6 and 9 hours and 13.1 +/- 5.7 ng.mL between 12 and 24 hours after onset. Elevated HGF levels were significantly more frequent than those of creatine kinase within 3 hours, and elevated levels correlated well with those of serum creatine kinase at 6-9 hours after onset of acute myocardial infarction. No increase in serum HGF value was found in patients with angina pectoris or other heart diseases. Thus, measurement of HGF is a sensitive method for early diagnosis of acute myocardial infarction.