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Creatinine and surveys: an assessment

B G Blijenberg¹, R J Brouwer, H Baadenhuijsen

¹Department of Clinical Chemistry, University Hospital Rotterdam-Dijkzigt, The Netherlands.

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies

|November 1, 1995

Summary

This study evaluated creatinine assay performance in the Netherlands. An enzymatic method demonstrated superior accuracy compared to Jaffé-based assays, highlighting the need for careful selection of creatinine testing procedures.

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Area of Science:

Clinical Chemistry
Analytical Chemistry

Background:

Creatinine assays are crucial for diagnosing kidney function.
Inter-laboratory variations in creatinine measurements can impact clinical decisions.
Standardization of creatinine testing remains an ongoing challenge.

Purpose of the Study:

To assess the performance of different creatinine assays used in The Netherlands between 1992-1994.
To compare the accuracy of enzymatic and Jaffé-based creatinine methods.
To evaluate the reliability of survey performance criteria for creatinine assays.

Main Methods:

Analysis of 113 samples (88 human sera, 25 animal sera) from creatinine surveys.
Review of results from 5 creatinine assays: 4 Jaffé-based and 1 enzymatic.
Evaluation of assay results against a High-Performance Liquid Chromatography (HPLC)-based reference method.

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Main Results:

The enzymatic creatinine assay exhibited significantly better performance than the Jaffé-based methods.
Considerable variability was observed among the different Jaffé reaction methods.
HPLC served as a reliable reference for evaluating assay accuracy.

Conclusions:

Enzymatic creatinine assays offer superior accuracy and reliability.
Caution is advised when interpreting survey performance data for creatinine assays.
Standardized and validated creatinine measurement methods are essential for accurate clinical assessment.