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Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures
S Stevens-Miles1, M A Goetz, G F Bills
1Merck Research Laboratories, Rahway, New Jersey 07065, USA.
The Journal of Antibiotics
|February 1, 1996
Abstract:
Cytosporin A, B and C, three antagonists of [125I]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp. during routine screening using semi-automated procedures. The most potent of these displayed an IC50 of 1.5-3 microM and was specific for angiotensin II AT2.