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Cloning of a putative ligand for the T1/ST2 receptor
M A Gayle1, J L Slack, T P Bonnert
1Immunex Corporation, Seattle, Washington 98101, USA.
The Journal of Biological Chemistry
|March 8, 1996
Abstract:
T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell surface protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays.