Recent advances in gene mutagenesis by site-directed recombination

Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis.

Glycobiology·2002

Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.

Cell·2001

Differential requirements for core2 glucosaminyltransferase for endothelial L-selectin ligand function in vivo.

Journal of immunology (Baltimore, Md. : 1950)·2001

Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase.

Cell·2001

Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice.

Blood·2001

Differential requirements for the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin.

Blood·2001

Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Inhibiting STAT1 Signaling and MHC Class I Expression.

The Journal of clinical investigation·2026

Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation.

The Journal of clinical investigation·2026

Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury.

The Journal of clinical investigation·2026

Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche in MASLD.

The Journal of clinical investigation·2026

METTL1-mediated m7G modification of valine tRNAs drives metabolic adaptation in pancreatic ductal adenocarcinoma.

The Journal of clinical investigation·2026

Targeting the E3 ubiquitin ligase RNF10 ameliorates metabolic dysfunction-associated steatohepatitis in mice.

The Journal of clinical investigation·2026

Ultrasound-Guided Revision Carpal Tunnel Release for Incomplete Open Carpal Tunnel Release: Using Magnetic Resonance Imaging to Guide Sonographic Access.

Journal of hand surgery global online·2026

Hepatocyte necroptosis triggers macrophage NOD-like receptor family pyrin domain-containing 3 inflammasome activation in N, N-dimethylformamide-induced liver injury.

Toxicology·2026

Systematic evaluation of the DNA repair machinery facilitated the development of efficient genome editing tools for the red yeast Rhodotorula toruloides.

Synthetic and systems biotechnology·2026

Bottom-up reconstruction of synthetic pyrenoids provides insights into the mechanisms and evolution of carbon concentration by EPYC1 proteins.

Nature plants·2026

The heavy ion-induced up-regulation of ZIP14 is mediated by the PKCNrf2 pathway.

Life sciences in space research·2026

Enantioselective Reduction of α,β-Dehydro-α-amido Carboxylic Acid Derivatives by Ene-Reductases.

Organic letters·2026

Related Experiment Videos

Recent advances in gene mutagenesis by site-directed recombination

Related Concept Videos

Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis.

Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding.

Differential requirements for core2 glucosaminyltransferase for endothelial L-selectin ligand function in vivo.

Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase.

Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice.

Differential requirements for the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin.

Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Inhibiting STAT1 Signaling and MHC Class I Expression.

Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation.

Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury.

Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche in MASLD.

METTL1-mediated m7G modification of valine tRNAs drives metabolic adaptation in pancreatic ductal adenocarcinoma.

Targeting the E3 ubiquitin ligase RNF10 ameliorates metabolic dysfunction-associated steatohepatitis in mice.

Ultrasound-Guided Revision Carpal Tunnel Release for Incomplete Open Carpal Tunnel Release: Using Magnetic Resonance Imaging to Guide Sonographic Access.

Hepatocyte necroptosis triggers macrophage NOD-like receptor family pyrin domain-containing 3 inflammasome activation in N, N-dimethylformamide-induced liver injury.

Systematic evaluation of the DNA repair machinery facilitated the development of efficient genome editing tools for the red yeast Rhodotorula toruloides.

Bottom-up reconstruction of synthetic pyrenoids provides insights into the mechanisms and evolution of carbon concentration by EPYC1 proteins.

The heavy ion-induced up-regulation of ZIP14 is mediated by the PKCNrf2 pathway.

Enantioselective Reduction of α,β-Dehydro-α-amido Carboxylic Acid Derivatives by Ene-Reductases.

Related Experiment Videos

Recent advances in gene mutagenesis by site-directed recombination

Related Concept Videos

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