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Related Experiment Videos

CNS involvement in mantle-cell lymphoma

E Montserrat1, F Bosch, A López-Guillermo

  • 1Postgraduate School of Hematology "Farreras Valentí," Barcelona, Spain.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|March 1, 1996
PubMed
Summary

Central nervous system (CNS) involvement in mantle cell lymphoma (MCL) occurred in 22% of patients, often with poor prognostic subtypes and advanced disease. This finding suggests CNS infiltration in MCL may be more common than previously thought.

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Area of Science:

  • Hematology
  • Oncology
  • Neurology

Background:

  • Central nervous system (CNS) involvement is a known complication in non-Hodgkin's lymphomas, with incidence varying by lymphoma histology.
  • Mantle cell lymphoma (MCL) is characterized by unique features, and CNS involvement has been infrequently reported.

Purpose of the Study:

  • To determine the incidence of CNS infiltration in patients with MCL.
  • To describe the clinical characteristics and outcomes of CNS involvement in MCL.

Main Methods:

  • Retrospective analysis of 22 patients diagnosed with MCL between 1987 and 1994.
  • Evaluation of the incidence of CNS involvement in this patient cohort.

Main Results:

  • CNS involvement was observed in 5 out of 22 MCL patients (22%), with a median onset of 18 months post-diagnosis.

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  • Patients with CNS involvement had poor MCL histologic subtypes and advanced disease at presentation.
  • Neurologic signs and detection of MCL cells in cerebrospinal fluid (CSF) confirmed CNS infiltration, often associated with resistant disease or relapse.

    • Conclusions:

    • The incidence of CNS involvement in MCL may be underestimated in current literature.
    • Further research is warranted to confirm the frequency of CNS infiltration in MCL.
    • Investigating risk factors, mechanisms, and clinical implications of CNS involvement in MCL is crucial.