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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Do silent brain infarctions predict the development of dementia after first ischemic stroke?
N M Bornstein1, A Y Gur, T A Treves
1Department of Neurology, Tel Aviv Medical Center, Israel.
Stroke
|May 1, 1996
Summary
Silent brain infarctions (SBI) do not predict dementia development after a first ischemic stroke. This study found no significant link between SBI and later-onset dementia in stroke patients.
Area of Science:
- Neurology
- Geriatrics
- Neuroimaging
Background:
- Silent brain infarctions (SBI) are prevalent in older adults.
- The association between SBI and dementia remains unclear.
- SBI are common incidental findings on neuroimaging.
Purpose of the Study:
- To investigate if silent brain infarctions (SBI) predict dementia development.
- To assess the relationship between SBI and incident dementia after a first ischemic stroke.
Main Methods:
- Retrospective analysis of CT scans from 175 non-demented patients with a first ischemic stroke.
- SBI defined as infarcts on CT not related to the acute stroke.
- Patients followed for 5 years to monitor for dementia onset using survival analysis.
Main Results:
- Dementia developed in 32% of patients over 5 years.
- No significant difference in dementia incidence was observed between patients with (35%) and without (30%) SBI.
- SBI were not found to be a predictor of dementia.
Conclusions:
- Silent brain infarctions do not appear to predict the development of dementia following an initial ischemic stroke.
- Further research may be needed to explore other risk factors for post-stroke dementia.
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