[Group and strain-specific determinants of the influenza virus nucleoprotein]

An antiserum to a purified nucleoprotein preparation of influenza virus recombinant A/MRC/11 obtained from A/Port Chalmers/1/73 and A/PR/8/34 strains, was examined for the presence of antibody before and after its adsorption with sodium sarcolysil sulphate-disrupted influenza. A viruses by the methods of radial and double immunodiffusion. The antiserum was found to contain both group- and strain-specific (for MRC-11 nucleoprotein) antibodies. In radial immunodiffusion tests MRC-11 nucleoprotein showed the greatest affinity to A/PR/8/34 nucleoprotein and differed from A/Scotland/860/74 and A/USSR/090/77.