Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Right ventricular function in chronically anemic fetal lambs

L E Davis1, A R Hohimer, G D Giraud

  • 1Department of Obstetrics, Pediatrics (Cardiology), Oregon Health Sciences University, Portland 97201-3098, USA.

American Journal of Obstetrics and Gynecology
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population-based study of the prevalence and management of self-reported high pain scores in patients with non-resected pancreatic adenocarcinoma.

The British journal of surgery·2019
Same author

Factors associated with receipt of symptom screening in the year after cancer diagnosis in a universal health care system: a retrospective cohort study.

Current oncology (Toronto, Ont.)·2019
Same author

Unexpected maturation of PI3K and MAPK-ERK signaling in fetal ovine cardiomyocytes.

American journal of physiology. Heart and circulatory physiology·2014
Same author

Insignificant response of the fetal placental circulation to arterial hypotension in sheep.

Journal of applied physiology (Bethesda, Md. : 1985)·2011
Same author

Atrial natriuretic peptide inhibits angiotensin II-stimulated proliferation in fetal cardiomyocytes.

The Journal of physiology·2010
Same author

Reduced systolic pressure load decreases cell-cycle activity in the fetal sheep heart.

American journal of physiology. Regulatory, integrative and comparative physiology·2010

Tissue edema in fetal anemia occurs despite the heart successfully adapting. This indicates fluid buildup is not due to cardiac failure but other factors in chronic anemia.

Area of Science:

  • Cardiovascular Physiology
  • Fetal Physiology
  • Anemia Research

Background:

  • Chronic fetal anemia is associated with increased extravascular fluid.
  • The underlying cause of this fluid accumulation, whether cardiac failure or adaptation, remains unclear.

Purpose of the Study:

  • To investigate whether extravascular fluid accumulation in chronic fetal anemia results from heart failure or successful cardiac adaptation.

Main Methods:

  • Right ventricular function curves were analyzed in ovine fetuses undergoing induced anemia.
  • Stroke volume and right atrial pressure were measured to determine cardiac adaptation breakpoints.
  • Myocardial blood flow was assessed using microsphere techniques.

Main Results:

Related Experiment Videos

  • Anemia significantly reduced oxygen content and hematocrit.
  • Despite unchanged right atrial pressure and increased stroke volume, indicating cardiac adaptation, extravascular fluid was present.
  • Coronary blood flow to both ventricles increased markedly.

Conclusions:

  • Tissue edema in severe fetal anemia occurs despite indicators of successful cardiac adaptation, such as normal right atrial pressure and increased stroke volume.
  • These findings suggest that extravascular fluid accumulation is not caused by cardiac failure in this condition.