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Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines
K Beyreuther1, G Multhaup, U Mönning
1ZMBH, Center for Molecular Biology, University of Heidelberg, Germany. bsa784@sun0.urz.uni-heidelberg.de
Annals of the New York Academy of Sciences
|January 17, 1996
Abstract:
We have identified and characterized the ligand binding properties of the Alzheimer's disease (AD) beta A4 amyloid protein precursor (APP), mapped the APP ligand binding sites and analyzed the regulation of APP expression, biogenesis and metabolism by components of the extracellular matrix (ECM) and cytokines.