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Construction, expression and characterisation of a single chain anti-tumour antibody (scFv)-IL-2 fusion protein
E Boleti1, M P Deonarain, R A Spooner
1Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
We describe the production and preliminary characterisation of a fusion protein between interleukin-2 and a single-chain Fv version of the H17E2 anti-placental alkaline phosphatase (PLAP) antibody. This molecule could be used to target interleukin-2 to PLAP-expressing tumours.
We describe the production and preliminary characterisation of a fusion protein between interleukin-2 and a single-chain Fv version of the H17E2 anti-placental alkaline phosphatase (PLAP) antibody. This molecule could be used to target interleukin-2 to PLAP-expressing tumours.