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Related Experiment Videos

Stabilized polyglycolic acid fibre-based tubes for tissue engineering

D J Mooney1, C L Mazzoni, C Breuer

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA.

Biomaterials
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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Polyglycolic acid (PGA) meshes were coated with poly(L-lactic acid) (PLLA) or poly(lactic-co-glycolic acid) (PLGA) to improve structural integrity. PLLA-coated PGA meshes demonstrated superior compression resistance and slower degradation, enabling successful tissue engineering in vivo.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Polyglycolic acid (PGA) meshes are suitable for cell transplantation but lack mechanical strength.
  • Enhancing the mechanical properties of PGA meshes is crucial for their application in tissue engineering.

Purpose of the Study:

  • To improve the mechanical stability and in vivo performance of PGA meshes.
  • To evaluate the efficacy of poly(L-lactic acid) (PLLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) coatings for PGA mesh stabilization.

Main Methods:

  • PGA meshes were formed into hollow tubes and coated with atomized solutions of PLLA or PLGA in chloroform.
  • The concentration of polymer solution and spray mass were varied to control fiber bonding.
  • Mechanical compression testing and in vivo implantation in rats were performed.

Related Experiment Videos

  • Cell seeding with smooth muscle and endothelial cells was conducted for in vitro tissue formation studies.

    • Main Results:

    • PLLA and PLGA coatings physically bonded adjacent PGA fibers, increasing compression resistance.
    • PLLA-coated tubes exhibited greater compression resistance and slower degradation compared to PLGA-coated tubes.
    • In vivo implantation showed that PLLA-coated tubes maintained structural integrity during tissue ingrowth, forming a stable tubular structure.
    • In vitro cell seeding resulted in tubular tissue formation with appropriate cell distribution.

    Conclusions:

    • PLLA and PLGA coatings effectively enhance the mechanical properties and stability of PGA meshes.
    • PLLA-coated PGA meshes offer superior performance for tissue engineering applications due to enhanced mechanical strength and slower degradation.
    • These stabilized PGA meshes show significant potential for engineering tubular tissues with specific cell arrangements.