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Pulmonary involvement in lymphoma

N Berkman1, R Breuer, M R Kramer

  • 1Institute of Pulmonology, Hadassah University Hospital & Hebrew University-Hadassah Medical School Jerusalem, Israel.

Leukemia & Lymphoma
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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Intrathoracic involvement, including mediastinal lymphadenopathy and pulmonary disease, is common in Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). Diagnosis relies on biopsy, with outcomes varying by lymphoma type and extent.

Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Intrathoracic involvement is a frequent complication of both Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL).
  • Mediastinal lymphadenopathy is the most common presentation, with distinct patterns observed in HD versus NHL.
  • Pulmonary parenchymal disease and pleural effusions are significant manifestations in lymphoma patients.

Purpose of the Study:

  • To review the common intrathoracic manifestations of HD and NHL.
  • To describe the radiological patterns of pulmonary lymphoma.
  • To outline diagnostic methods and factors influencing prognosis.

Main Methods:

  • Review of literature on intrathoracic lymphoma.
  • Analysis of radiological patterns (nodular, bronchovascular-lymphangitic, pneumonic-alveolar).

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  • Description of diagnostic techniques including biopsy and immunostaining.

    • Main Results:

    • Pulmonary parenchymal disease affects 38% of HD and 24% of NHL cases.
    • Pleural effusion occurs in 16% of lymphoma patients, often linked to lymphatic obstruction or direct tumor involvement.
    • Radiological patterns of pulmonary lymphoma include nodular, bronchovascular-lymphangitic, and pneumonic-alveolar.

    Conclusions:

    • Intrathoracic involvement in lymphoma presents with diverse radiological patterns.
    • Accurate diagnosis through biopsy and immunostaining is crucial for determining treatment and prognosis.
    • Understanding these manifestations aids in timely diagnosis and management of lymphoma.