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Published on: November 8, 2011
Transformation of essential thrombocythaemia to T cell acute lymphoblastic leukaemia
L C Berkahn1, J Nelson, P A Ockelford
1Department of Haematology, Auckland Hospital, New Zealand.
Leukemia & Lymphoma
|January 1, 1996
Abstract:
Leukaemic transformation of essential thrombocythaemia is a rare event and is usually associated with previous treatment with either alkylating agents or radioactive phosphorous. We describe a patient with essential thrombocythaemia who developed an acute leukaemia of T cell phenotype following hydroxyurea therapy. The T cell phenotype of the blasts suggests the target cell for leukaemic transformation was a pluripotential stem cell.

