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Porokeratosis and cutaneous malignancy. A review
1Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Background:
Porokeratosis is a disorder of epidermal keratinization manifested clinically by a raised border and histologically by a cornoid lamella. While cutaneous malignancy has been reported to arise in porokeratosis, the risk remains unknown. In the past it has been associated with a history of radiation therapy.
Objective:
The purpose of this study is to estimate the frequency of cutaneous malignancy arising in porokeratosis and define those patients who are at highest risk.
Methods:
All cases in the English language literature in the last 30 years were reviewed.
Results:
Twenty-one (7.5%) of 281 cases reported revealed a malignancy arising within porokeratosis. Large lesions, those of long-standing duration, and the linear type were at greatest risk. Radiation therapy was an infrequently identified risk factor.
Conclusion:
Porokeratosis is a premalignant condition, with certain groups of patients at greatest risk for malignant transformation.