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Updated: Aug 8, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Modulation of complement-mediated immune damage by intravenous immune globulin
1Laboratory of Clinical Investigations, National Institute of Allergy and infectious Diseases, Bethesda, Maryland 20892, USA.
High-dose intravenous immune globulin (IVIG) may treat immune disorders by interfering with the complement system. This therapy suppressed immune cell clearance and prevented critical organ damage in animal models.
Area of Science:
- Immunology
- Complement System Biology
Background:
- High-dose intravenous immune globulin (IVIG) is used for immune disorders.
- Its mechanism may involve the complement system.
Purpose of the Study:
- To investigate if IVIG interferes with the complement system.
- To explore IVIG's role in complement-mediated pathology.
Main Methods:
- Animal models of complement-mediated pathology.
- In vitro complement assays.
- Studies on human diseases with similar pathogenesis.
Main Results:
- IVIG suppressed clearance of IgM-sensitized erythrocytes.
- IVIG prevented pulmonary endothelial cell lesions in 75% of animals during Forssman shock.
- IVIG inhibited in vitro uptake of C3b and C4b onto immune complexes.
Conclusions:
- IVIG interacts with activated complement components.
- IVIG prevents complement deposition on target cells.
- IVIG is a potential modulator of inappropriate complement activation.
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