Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human immunodeficiency virus and AIDS in Uganda

R D Mugerwa1, L H Marum, D Serwadda

  • 1Department of Medicine, Makerere University Medical School, Kampala, Uganda.

East African Medical Journal
|January 1, 1996
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HIV incidence among non-migrating persons following a household migration event: a population-based, longitudinal study in Uganda.

medRxiv : the preprint server for health sciences·2023
Same author

Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda.

Mucosal immunology·2013
Same author

Household ventilation and tuberculosis transmission in Kampala, Uganda.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2013
Same author

Foreskin T-cell subsets differ substantially from blood with respect to HIV co-receptor expression, inflammatory profile, and memory status.

Mucosal immunology·2011
Same author

A randomized trial of punctuated antiretroviral therapy in Ugandan HIV-seropositive adults with pulmonary tuberculosis and CD4⁺ T-cell counts of ≥ 350 cells/μL.

The Journal of infectious diseases·2011
Same author

Comparison of the Abbott m2000 HIV-1 Real-Time and Roche AMPLICOR Monitor v1.5 HIV-1 assays on plasma specimens from Rakai, Uganda.

International journal of STD & AIDS·2011

Uganda faces a significant HIV-1 epidemic, with 1.5 million infected. While some prevalence rates are declining, opportunistic infections like tuberculosis are increasing, highlighting ongoing challenges in HIV management.

Area of Science:

  • Public Health
  • Epidemiology
  • Infectious Diseases

Background:

  • HIV-1, initially termed "slim disease", emerged in Uganda in 1982 and is now a major health crisis.
  • Approximately 1.5 million Ugandans are infected, primarily through heterosexual contact, contributing to a substantial portion of adult mortality.
  • While urban antenatal and rural cohort HIV-1 seroprevalence rates show recent declines, the epidemic's impact persists.

Purpose of the Study:

  • To summarize the current state of the HIV-1 epidemic in Uganda.
  • To detail the clinical manifestations and transmission patterns of HIV-1 in Uganda.
  • To highlight the Ugandan response strategies and research advancements.

Main Methods:

  • Review of epidemiological data on HIV-1 prevalence and transmission in Uganda.
Keywords:
Acquired Immunodeficiency Syndrome--prevention and controlAfricaAfrica South Of The SaharaBiologyBlood Transfusion--side effectsCancerCardiovascular EffectsCritiqueDeveloping CountriesDiseasesEastern AfricaEnglish Speaking AfricaGastrointestinal EffectsHiv Infections--transmissionInfectionsLiterature ReviewNeoplasmsNeurologic EffectsPhysiologyRespiratory InfectionsSigns And SymptomsTreatmentTuberculosisUgandaViral Diseases

Related Experiment Videos

  • Analysis of clinical manifestations, including opportunistic infections and co-infections.
  • Assessment of mother-to-child transmission rates and research program development.

    • Main Results:

    • Heterosexual transmission is the predominant mode of HIV-1 spread, affecting 1.5 million Ugandans.
    • Increased incidence of tuberculosis and specific HIV-associated conditions like Kaposi sarcoma and cryptococcal meningitis are observed.
    • Mother-to-child transmission accounts for approximately 10% of cases, with a 26% transmission rate in studied cohorts.
    • Declining seroprevalence rates noted in specific urban and rural populations.

    Conclusions:

    • Uganda's response to the HIV-1 epidemic is characterized by societal engagement, governmental multisectoral efforts, and innovative programs like large-scale testing and The AIDS Support Organization (TASO).
    • Despite some positive trends in prevalence, the persistent burden of opportunistic infections and mother-to-child transmission necessitates continued research and intervention.
    • Well-established epidemiological and clinical research programs in Uganda are crucial for addressing tuberculosis, maternal/pediatric HIV, and sexually transmitted infections.