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Xanthoquinodin B3, a new anticoccidial agent produced by Humicola sp. FO-888
1Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
The Journal of Antibiotics
|March 1, 1996
Abstract:
Xanthoquinodin B3, a new component of anticoccidial xanthoquinodins, which was detected in the culture broth of Humicola sp. FO-888, was isolated by heat treatment of the xanthoquinodins complex. Structural elucidation indicated that xanthoquinodin B3 has the same heterodimer of xanthone- and anthraquinone-derived monomers as other xanthoquinodins. Schizont formation of monensin-resistant Eimeria tenella in BHK-21 cells was inhibited by xanthoquinodin B3 at concentrations greater than 0.035 microM.