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Role of Friend-associated lymphatic leukemia virus in immunization against Friend leukemia complex
Experientia
|April 15, 1977
Abstract:
Mice inoculated with Friend leukemia complex (FLC) pretreated with concanavalin A are resistant to FLC challenge only when they have become infected with the FLC-associated lymphatic leukemia virus (LLV). In interpreting states of resistance to FLC induced by various immunizing procedures, the possibility that immunity is sustained by an unrecognized LLV infection should always be considered.
Insights
Mice pretreated with concanavalin A resist Friend leukemia complex (FLC) challenge only if infected with the FLC-associated lymphatic leukemia virus (LLV). Unrecognized LLV infection may sustain resistance to FLC, a factor to consider in immunity studies.
Area of Science:
- Immunology
- Virology
- Oncology
Background:
- Friend leukemia complex (FLC) is a viral disease in mice.
- Concanavalin A is a plant lectin used to stimulate immune responses.
- Understanding resistance mechanisms to FLC is crucial for cancer research.
Purpose of the Study:
- To investigate the role of lymphatic leukemia virus (LLV) infection in FLC resistance.
- To determine if LLV infection is a prerequisite for concanavalin A-induced resistance to FLC.
Main Methods:
- Mice were inoculated with FLC and pretreated with concanavalin A.
- Infection status with FLC-associated LLV was assessed.
- Resistance to FLC challenge was evaluated in relation to LLV infection.
Main Results:
- Resistance to FLC challenge was observed only in mice that were infected with LLV.
- Concanavalin A pretreatment alone did not confer resistance without LLV infection.
Conclusions:
- LLV infection is essential for concanavalin A-mediated resistance to FLC in mice.
- Unrecognized LLV infection should be considered when evaluating FLC resistance induced by immunizing procedures.