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Urolithiasis and cystic fibrosis
L A Matthews1, C F Doershuk, R C Stern
1Department of Urology, University Hospitals of Cleveland, Ohio 44106-5046, USA.
The Journal of Urology
|May 1, 1996
Summary
Cystic fibrosis patients may have a higher risk of developing urolithiasis (kidney stones). This study found a 5.5% prevalence of kidney stones in cystic fibrosis patients.
Area of Science:
- Nephrology
- Pulmonology
- Genetics
Background:
- Cystic fibrosis is a genetic disorder affecting multiple organs.
- The risk of urolithiasis in cystic fibrosis patients is not well-established.
Purpose of the Study:
- To investigate the prevalence of urolithiasis in cystic fibrosis patients.
- To determine if cystic fibrosis is associated with an increased risk of kidney stone formation.
Main Methods:
- Telephone interviews with 201 cystic fibrosis patients (age > 15).
- Confirmation of urolithiasis history via chart review.
- Inclusion criteria required documented evidence of urolithiasis (imaging or stone passage).
Main Results:
- 11 out of 201 cystic fibrosis patients (5.5%) had documented urolithiasis.
- Seven patients experienced two or more episodes of urolithiasis.
- The mean age at the first episode of urolithiasis was 27.0 years.
Conclusions:
- Cystic fibrosis patients may face an elevated risk of developing urolithiasis.
- Findings suggest a potential link between cystic fibrosis and kidney stone disease compared to general population rates.