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From DNA sequence to biological function

S G Oliver1

  • 1Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, UK.

Nature
|February 15, 1996
PubMed
Summary
This summary is machine-generated.

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Genome sequencing rapidly identifies new genes, but their functions remain unknown. A systematic approach is needed to understand gene function, especially in model organisms like yeast.

Area of Science:

  • Genomics
  • Molecular Biology
  • Yeast Genetics

Background:

  • Genome sequencing accelerates gene discovery significantly beyond classical genetics.
  • The biological functions of approximately 50% of newly discovered genes are currently unknown.
  • Exploiting vast amounts of genome sequence data necessitates efficient methods for determining gene function.

Purpose of the Study:

  • To outline a systematic approach for discovering gene function.
  • To discuss strategies for functional genomics analysis.
  • To contextualize these strategies within the model eukaryote Saccharomyces cerevisiae.

Main Methods:

  • Review and discussion of potential strategies for functional genomics.
  • Focus on Saccharomyces cerevisiae as a model organism for functional analysis.

Related Experiment Videos

  • Consideration of the implications of a completed yeast genome sequence.

    • Main Results:

    • Identification of a critical need for systematic gene function discovery.
    • Exploration of various strategies applicable to functional genomics.
    • Highlighting Saccharomyces cerevisiae as a key model system.

    Conclusions:

    • A systematic approach is essential to fully utilize genome sequencing data.
    • Functional analysis in model organisms like yeast is crucial for understanding gene roles.
    • Developing efficient methods for gene function discovery is a priority in modern biology.