Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Limbal transplantation

D T Tan1, L A Ficker, R J Buckley

  • 1Singapore National Eye Centre, Singapore.

Ophthalmology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Limbal allograft transplantation successfully restored ocular surfaces in most patients with severe eye conditions. This procedure may be a better alternative than autografting for bilateral ocular surface disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis (Revised Edition 2017; First edition 2007).

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2018
Same author

Assessment and management of dry eye disease.

Eye (London, England)·2018
Same author

Macrophage polarisation affects their regulation of trophoblast behaviour.

Placenta·2016
Same author

Risk factors for contact lens-related microbial keratitis in Singapore.

Eye (London, England)·2015
Same author

Comparison of intra-ocular pressure changes with liquid or flat applanation interfaces in a femtosecond laser platform.

Scientific reports·2015
Same author

A mouse model of lamellar intrastromal femtosecond laser keratotomy: ultra-structural, inflammatory, and wound healing responses.

Molecular vision·2011

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Transplantation Immunology

Background:

  • Limbal transplantation is a surgical procedure for ocular surface disorders caused by stem cell deficiency.
  • This study evaluated limbal allograft transplantation versus autograft transplantation in 18 patients with conditions like aniridia keratopathy and chemical injury.

Observation:

  • Limbal allograft transplantation restored ocular surfaces in 7 out of 9 cases, leading to improved vision and reduced symptoms.
  • Graft failure in allografts occurred due to infection and rejection; autograft failures were linked to pre-existing conditions in the donor eye.

Findings:

  • Limbal allograft transplantation demonstrated a high success rate in restoring ocular surface stability and visual function.
  • Autograft failures were associated with epithelial dysplasia in the donor eye, suggesting subclinical disease.

Related Experiment Videos

Implications:

  • Limbal allograft transplantation is a promising alternative for patients with bilateral ocular surface disease.
  • Further research is needed to optimize immunosuppression protocols for allograft recipients.