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Related Experiment Videos

Septal ultrastructure in Candida albicans

K C Rajasingham, R A Cawson

    Acta Microbiologica Polonica
    |January 1, 1978
    PubMed
    Summary

    The study reveals distinct differences in the septa of Candida albicans, with saprophytic forms showing a unique perforated septum and invasive forms exhibiting a solid, non-perforated structure. These findings differ from other pathogenic fungi.

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    An ultrastructural evaluation of the reaction of the host cell membrane to the invasive phase of Candida albicans.

    Cytobios·1992

    Area of Science:

    • Mycology
    • Cell Biology
    • Medical Mycology

    Background:

    • Septal ultrastructure is crucial for understanding fungal cell division and pathogenicity.
    • Candida albicans is an opportunistic fungal pathogen causing oral candidosis.
    • Previous studies have characterized septal ultrastructure in various pathogenic fungi.

    Purpose of the Study:

    • To investigate and compare the fine structural differences in the septa of Candida albicans during saprophytic and invasive growth phases.
    • To elucidate the unique ultrastructural characteristics of Candida albicans septa.
    • To compare these findings with existing knowledge of septal ultrastructure in other fungi.

    Main Methods:

    • Fine structural analysis using electron microscopy.
    • Comparative study of Candida albicans grown in vitro (saprophytic) and in vivo (invasive form in oral candidosis).

    Main Results:

    • Saprophytic Candida albicans exhibits septa with a unique central perforation, appearing as aggregated fine canaliculi connecting cells.
    • Invasive Candida albicans shows non-perforated, solid septa.
    • The observed septal ultrastructure in Candida albicans does not align with previously reported studies on other deutromycetous fungi.

    Conclusions:

    • The septal morphology of Candida albicans varies significantly between its saprophytic and invasive states.
    • The unique perforated septum in saprophytic Candida albicans may play a role in cell-to-cell communication or nutrient exchange.
    • The solid septum in invasive Candida albicans might be associated with increased structural integrity during host tissue invasion.

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