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Coronary flow reserve: noninvasive measurement in humans with breath-hold velocity-encoded cine MR imaging
H Sakuma1, L M Blake, T M Amidon
1Department of Radiology, University of California, San Francisco 94143-0628, USA.
Purpose:
To measure coronary vasodilator reserve with breath-hold velocity-encoded cine magnetic resonance (MR) imaging.
Materials And Methods:
Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocity-encoded cine images were acquired at seven to 13 temporal phases in 25 seconds, with k-space segmentation and view-sharing reconstruction (+/- 1 m/sec velocity-encoding value) (repetition time msec/echo time msec = 16/9). Flow velocity in the left anterior descending (LAD) artery was measured twice before and twice after administration of dipyridamole (0.56 mg per kilogram of body weight).
Results:
Peak diastolic coronary flow velocity in the LAD artery was 14.8 cm/sec +/- 1.9 (mean +/- standard deviation) in the baseline state. It increased significantly (P< .01) to 46.3 cm/sec +/- 10.2 after dipyridamole administration, with an average coronary reserve of 3.14 +/- 0.59. Interstudy and interobserver reproducibilities for measurement of peak diastolic velocity were, respectively, 9.5% +/- 1.6 and 7.0% +/- .2.5 in the baseline state and 6.8% +/- 2.2 and 3.4% +/- 1.5 after dipyridamole administration.
Conclusion:
Breath-hold velocity-encoded cine MR imaging provided reproducible assessment of coronary flow reserve in humans.