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Gliomatosis cerebri

R del Carpio-O'Donovan1, I Korah, A Salazar

  • 1Department of Radiology, Montreal General Hospital, McGill University, Quebec, Canada.

Radiology
|March 1, 1996
PubMed
Summary

Magnetic resonance (MR) imaging is superior for detecting gliomatosis cerebri, a rare brain tumor. This study found MR imaging better characterized tumor extent compared to computed tomography (CT) scans.

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Area of Science:

  • Neurology
  • Radiology
  • Oncology

Background:

  • Gliomatosis cerebri is an uncommon central nervous system neoplasm.
  • Characterizing its imaging features is crucial for diagnosis and management.

Purpose of the Study:

  • To define the computed tomographic (CT) and magnetic resonance (MR) imaging characteristics of gliomatosis cerebri.
  • To compare the diagnostic utility of CT and MR imaging for this condition.

Main Methods:

  • Retrospective review of CT and MR imaging studies from 22 patients diagnosed with gliomatosis cerebri.
  • Correlation of imaging findings with autopsy (n=5) or biopsy confirmation.
  • Assessment of tumor distribution, extent, and progression.

Main Results:

  • Gliomatosis cerebri involved multiple brain lobes in all patients, with frequent extension to the corpus callosum, basal ganglia, and thalamus.
  • MR imaging demonstrated widespread infiltration with hyperintensity on proton-density and T2-weighted images.
  • CT scans showed hypo- or isoattenuation without contrast enhancement; MR imaging revealed a greater tumor extent than CT.

Conclusions:

  • Magnetic resonance (MR) imaging is the preferred modality for detecting and characterizing gliomatosis cerebri.
  • The characteristic imaging pattern is infiltrative, leading to enlargement of cerebral structures.

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