Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular filling pattern in uncomplicated obesity

G F Mureddu1, G de Simone, R Greco

  • 1Institute of Internal Medicine and Metabolic Diseases, Federico II University Hospital, Naples, Italy.

The American Journal of Cardiology
|March 1, 1996
PubMed
Summary

Obesity impairs left ventricular (LV) diastolic function, specifically prolonging isovolumic relaxation time, independent of LV mass. Early filling abnormalities in obesity are linked to increased LV mass.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fructose and salt induce sex- and ovary dependent cardiac hypertrophy in Dahl salt-sensitive rats.

Frontiers in cardiovascular medicine·2026
Same author

Cross-linked carboxymethyl cellulose and silk proteins for dry eye disease management and corneal wound healing: in vivo and in vitro results.

European review for medical and pharmacological sciences·2026
Same author

Dissection of Nitric Oxide binding pathway in Nitrobindins reveals hidden structural details.

International journal of biological macromolecules·2025
Same author

Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation.

Stem cell research & therapy·2024
Same author

Erratum to "Second Consensus on Treatment of Patients Recently Diagnosed with Mild Hypertension and Low Cardiovascular Risk". [YMCD 45/10 (October 2020) 100653].

Current problems in cardiology·2021
Same author

Home mobile radiography service in the COVID-19 era.

European review for medical and pharmacological sciences·2021

Area of Science:

  • Cardiology
  • Obesity Research
  • Echocardiography

Background:

  • Uncomplicated obesity may affect cardiac function.
  • Left ventricular (LV) diastolic dysfunction is a potential concern.

Purpose of the Study:

  • To assess if obesity is linked to systolic dysfunction or impaired LV filling.
  • To investigate the relationship between obesity, LV mass, and diastolic function.

Main Methods:

  • Doppler echocardiography in 40 obese and 40 normal-weight subjects.
  • Matched for age and sex, all subjects were normotensive and asymptomatic.
  • Evaluated LV mass, endocardial/midwall shortening, and diastolic filling parameters.

Main Results:

  • Obese subjects had higher LV mass index.

Related Experiment Videos

  • Prolonged isovolumic relaxation time in obese individuals was independent of LV mass.
  • Abnormalities in early diastolic filling (E velocity, deceleration time, E/A ratio) were observed in obese subjects.

    • Conclusions:

    • Obesity is associated with primary impairment of LV isovolumic relaxation.
    • Abnormalities in early passive filling flow in obesity correlate with increased LV mass.
    • Systolic function (shortening) was not significantly different between groups.