Related Experiment Videos
Can serial tilt testing be used to evaluate therapy in neurally mediated syncope?
C A Morillo1, G J Klein, B J Gersh
1Department of Medicine, Medical College of Virginia, Richmond, USA.
The American Journal of Cardiology
|March 1, 1996
Summary
Serial head-up tilt testing may not effectively guide neurally mediated syncope therapy. Further large placebo-controlled trials are needed to confirm the therapeutic efficacy of this diagnostic method.
Area of Science:
- Cardiology
- Neurology
- Clinical Trials
Background:
- Neurally mediated syncope (NMS) is a common cause of recurrent syncope.
- Head-up tilt testing (HUTT) is frequently used to diagnose NMS.
- The efficacy of serial HUTT in guiding NMS therapy remains debated.
Purpose of the Study:
- To review the role of serial head-up tilt testing (HUTT) in evaluating the effectiveness of treatments for neurally mediated syncope.
- To assess the current evidence supporting the use of serial HUTT responses to guide NMS therapy.
Main Methods:
- Literature review of studies investigating serial head-up tilt testing in neurally mediated syncope.
- Analysis of evidence regarding the correlation between HUTT response and therapeutic outcomes.
Main Results:
- Current evidence suggests that serial HUTT responses may not be a reliable indicator for guiding NMS therapy.
- The utility of HUTT in assessing treatment efficacy requires further investigation.
Conclusions:
- Guiding neurally mediated syncope therapy based on serial head-up tilt test results may not be appropriate.
- Large-scale, placebo-controlled trials are necessary to definitively establish the role of serial HUTT in evaluating therapeutic efficacy for NMS.