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The proteinase 3 (PRTN3) gene is localized on 19p13.3 and is distal to the E2A gene
1Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Annales De Genetique
|January 1, 1995
Abstract:
The gene encoding the proteinase 3. (PRTN3, myeloblastin) was localized to chromosomal band 19p13.3 by radioactive and fluorescent in situ hybridization (FISH) to normal metaphase chromosomes. This localization was shown to be telomeric to the E2A gene by performing FISH to metaphases with balanced translocation t(1;19)((q23;p13) characteristic for a pre-B subtype of acute leukemia. In the unbalanced form of this translocation, a monoallelic loss of the PRTN3 locus was observed with FISH.