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Severe hyponatremia during therapy with fluoxetine
W L ten Holt1, C E van Iperen, G Schrijver
1Department of Internal Medicine, Red Cross Hospital, Beverwijk, The Netherlands.
Archives of Internal Medicine
|March 25, 1996
Summary
Severe hyponatremia, a dangerous electrolyte imbalance, occurred in two elderly patients during fluoxetine treatment. This condition was likely due to the inappropriate secretion of antidiuretic hormone.
Area of Science:
- Geriatric Medicine
- Clinical Pharmacology
- Endocrinology
Background:
- Hyponatremia is a common electrolyte disturbance, particularly in the elderly.
- Antidepressant medications, including selective serotonin reuptake inhibitors (SSRIs), have been associated with hyponatremia.
- The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a known cause of euvolemic hyponatremia.