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Published on: August 25, 2017
Nutritional status and mortality in chronic obstructive pulmonary disease
K Gray-Donald1, L Gibbons, S H Shapiro
1School of Dietetics and Human Nutrition, Department of Epidemiology and Biostatistics, McGill University, Montréal, Québec, Canada.
Summary
Low body weight is linked to poorer survival in severe chronic obstructive pulmonary disease (COPD) patients. This finding highlights nutritional status as a key factor in COPD prognosis, suggesting potential for interventions.
Area of Science:
- Pulmonology
- Nutritional Science
- Prognostic Research
Background:
- Severe chronic obstructive pulmonary disease (COPD) significantly impacts patient prognosis.
- The influence of nutritional status on COPD outcomes requires further elucidation.
Purpose of the Study:
- To investigate the role of nutritional status in predicting survival for individuals with severe COPD.
- To identify specific nutritional and physiological markers associated with mortality in COPD patients.
Main Methods:
- A cohort study of 348 Canadian adults with severe COPD, followed for 3-5 years.
- Evaluation included lung function, body weight, diffusing capacity, maximal respiratory pressures (PImax, PEmax), and blood gases.
- Cox regression models were used to analyze predictors of survival and respiratory mortality.
Main Results:
- Low body mass index (BMI) and home oxygen use were independently associated with reduced survival in the total cohort.
- In hospitalized patients, elevated PaCO2, low BMI, low PImax, and low diffusing capacity predicted respiratory mortality.
- Factors like PaO2, FEV1, PEmax, age, smoking, and gender did not significantly predict survival.
Conclusions:
- Low body weight, a potentially modifiable factor, is significantly associated with respiratory mortality in severe COPD.
- Further intervention trials are needed to determine if low body weight is a causal factor or a marker of declining health.
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