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Acute hexogen poisoning after occupational exposure

F Testud1, J M Glanclaude, J Descotes

  • 1Poison Information and Toxicovigilance Centre, E. Herriot Hospital, Lyon, France.

Journal of Toxicology. Clinical Toxicology
|January 1, 1996
PubMed
Summary

Exposure to hexogen (cyclonite, RDX) nitrate explosive can cause poisoning, including seizures in previously healthy individuals. This case highlights a rare occupational hazard in ammunition plants.

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Area of Science:

  • Occupational toxicology
  • Neurotoxicology
  • Chemical safety

Background:

  • Hexogen (cyclonite, RDX) nitrate explosive is an uncommon cause of poisoning.
  • Occupational exposure to RDX can occur in industries manufacturing explosives.
  • Understanding the toxicological profile of RDX is crucial for workplace safety.

Observation:

  • A 42-year-old male ammunition plant worker experienced grand mal seizures after prolonged sieving of fine RDX powder.
  • Initial medical evaluation showed no abnormalities, but seizures recurred hours after admission.
  • Neurological imaging (EEG, CT, MRI) revealed no structural or functional abnormalities.

Findings:

  • The patient recovered fully without lasting effects, suggesting a transient neurotoxic effect of RDX.

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  • The case report details a rare instance of RDX-induced poisoning manifesting as seizures.
  • No prior history of epilepsy or other predisposing factors were identified in the patient.

    • Implications:

    • This case underscores the potential neurotoxic risks associated with occupational RDX exposure.
    • It highlights the importance of implementing stringent safety protocols in ammunition plants.
    • Further toxicological data on RDX is needed to fully understand and mitigate poisoning risks.