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Related Experiment Videos

Intravesical electrical stimulation induces a prolonged decrease in micturition threshold volume in the rat

C H Jiang1, S Lindström

  • 1Department of Cell Biology, University of Linköping, Linköping, Sweden.

The Journal of Urology
|April 1, 1996
PubMed
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Intravesical electrical stimulation (IVES) significantly reduces the micturition reflex threshold volume in rats. This effect, mediated by bladder afferents, suggests IVES may modulate voiding disorders.

Area of Science:

  • Neuroscience
  • Urology
  • Physiology

Background:

  • Intravesical electrical stimulation (IVES) is a clinical treatment for voiding disorders.
  • The precise mechanism of IVES on the micturition reflex requires objective investigation.

Purpose of the Study:

  • To provide objective evidence of micturition reflex modulation by intravesical electrical stimulation (IVES).
  • To investigate the underlying mechanisms of IVES-induced changes in the micturition reflex.

Main Methods:

  • Experiments were conducted on 41 anesthetized female rats.
  • Intravesical electrical stimulation (20 Hz, 7-11 mA) was applied via a bladder catheter.
  • Micturition reflex threshold volume was measured using cystometry.

Main Results:

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  • IVES significantly decreased the micturition reflex threshold volume to 82% of control values (p<0.001).
  • The observed effect was reversible, lasting approximately 1 hour.
  • Blockade of bladder nerves during IVES prevented the decrease in threshold volume.

Conclusions:

  • Intravesical electrical stimulation induces a prolonged modulation of the micturition reflex in rats.
  • The effect is attributed to the activation of bladder mechanoreceptor afferents.
  • This modulation, potentially involving enhanced synaptic transmission, may explain the therapeutic benefits of IVES for voiding disorders.