Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Carbohydrate antigens as tumor marker]

H Ohkura1

  • 1Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.

Nihon Geka Gakkai Zasshi
|February 1, 1996
PubMed
Summary

Carbohydrate tumor markers, like sialyl Lewis A and X, aid in monitoring advanced cancers but lack specificity for early detection. Their role in cancer metastasis is an active area of research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2004
Same author

Dis1/TOG universal microtubule adaptors - one MAP for all?

Journal of cell science·2001
Same author

Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles.

Nature cell biology·2001
Same author

A trial toward the synthesis of gamma-fluorinated beta-amino-alpha-thiohydroxyamino acid: a finding of desulfurizative C-C bond formation in thio-Wittig-type rearrangement of S-(N-aryl-trifluoroacetimidoyl)thioglycolates.

The Journal of organic chemistry·2001
Same author

[Tumor marker in gastric cancer].

Nihon rinsho. Japanese journal of clinical medicine·2001
Same author

Metaphase arrest with centromere separation in polo mutants of Drosophila.

The Journal of cell biology·2001

Area of Science:

  • Oncology
  • Biochemistry
  • Immunology

Background:

  • Carbohydrate chains on cancer cells have been extensively studied since S. Hakomori's pioneering work.
  • Monoclonal antibodies targeting these carbohydrate antigens are developed and utilized as tumor markers in clinical practice.
  • Current tumor markers are often not specific to cancer, negative in early stages, and primarily used for monitoring advanced or recurrent disease.

Purpose of the Study:

  • To review the utility and limitations of current carbohydrate tumor markers.
  • To discuss the challenges and discrepancies in commercial systems for sugar chain tumor markers.
  • To explore the functional role of sialylated carbohydrate antigens in cancer metastasis.

Main Methods:

  • Review of existing literature on carbohydrate tumor markers.
  • Analysis of data on positive rates of serum markers in major organic sites (presented in a table, not included in abstract text).
  • Discussion of the properties and clinical applications of various tumor markers.

Main Results:

  • Many carbohydrate tumor markers are not specific to cancer and are elevated mainly in advanced or recurrent stages.
  • Commercial systems for sugar chain tumor markers exhibit similarities and discrepancies.
  • Sialylated carbohydrate antigens, such as sialyl Lewis A and sialyl Lewis X, show strong affinities with cell-adhesion molecules.

Conclusions:

  • Carbohydrate tumor markers are valuable for monitoring patients with advanced or recurrent cancers but have limitations in early diagnosis and specificity.
  • The interaction of sialylated carbohydrate antigens with cell-adhesion molecules suggests their involvement in distant cancer metastasis.
  • Further research is needed to improve the specificity and utility of carbohydrate-based cancer diagnostics and therapeutics.

Related Experiment Videos