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Related Experiment Videos

Mesalamine-induced lung toxicity

A Bitton1, M A Peppercorn, J P Hanrahan

  • 1Center for Inflammatory Bowel Disease, Beth Israel Hospital, Boston, Massachusetts, USA.

The American Journal of Gastroenterology
|May 1, 1996
PubMed
Summary
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Rare lung toxicity from 5-aminosalicylate (5-ASA) agents, like oral mesalamine, can occur. This case highlights mesalamine-induced lung damage in ulcerative colitis patients with respiratory symptoms.

Area of Science:

  • Pulmonology
  • Gastroenterology
  • Pharmacology

Background:

  • 5-aminosalicylate (5-ASA) agents are commonly used for ulcerative colitis.
  • Lung toxicity is a rare but serious adverse effect associated with 5-ASA medications.

Observation:

  • A 32-year-old woman with ulcerative colitis presented with progressive shortness of breath.
  • The patient was taking oral mesalamine, a 5-ASA drug.

Findings:

  • The patient exhibited bilateral pulmonary infiltrates and peripheral eosinophilia.
  • Histological examination revealed acute pneumonitis, consistent with drug-induced lung injury.

Implications:

  • Mesalamine-induced lung damage should be considered in patients with unexplained respiratory symptoms while on this medication.

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  • This case underscores the importance of recognizing rare adverse drug reactions for timely diagnosis and management.