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An incremental dosing protocol for women with severe vaginal trichomoniasis and adverse reaction to metronidazole
M D Pearlman1, C Yashar, S Ernst
1Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, MI 48109-0718, USA.
Objective:
Our purpose was to develop and test an incremental dosing protocol for women with adverse reaction to metronidazole and severe symptomatic Trichomonas vaginitis.
Study Design:
Two women with documented Trichomonas infection and presumed metronidazole allergy were initially treated with a number of alternative methods without success. With persistent severe symptoms associated with their infection, these women were admitted to the hospital and underwent an intravenous incremental metronidazole dosing protocol.
Results:
Both patients were successfully treated without adverse event. They are both symptom-free and apparently cured several months after treatment.
Conclusion:
This protocol offers a new therapeutic option to women with adverse metronidazole reactions and severe symptomatic Trichomonas vaginitis resistant to treatment with nonmetronidazole therapy.