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Related Experiment Videos

Pulmonary endothelial permeability changes after major lung resection

D A Waller1, P Keavey, L Woodfine

  • 1Regional Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne, United Kingdom.

The Annals of Thoracic Surgery
|May 1, 1996
PubMed
Summary
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Pulmonary endothelial permeability increases after pneumonectomy, not lobectomy. Preoperative neutrophil activation and remaining pulmonary vasculature adaptation may cause this, leading to lung edema.

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Surgical Oncology

Background:

  • Postpneumonectomy pulmonary edema is linked to increased pulmonary endothelial permeability.
  • This study investigates pulmonary endothelial permeability changes after major lung resection.

Purpose of the Study:

  • To investigate changes in pulmonary endothelial permeability following major lung resection.
  • To identify potential etiologic factors for postpneumonectomy pulmonary edema.

Main Methods:

  • Lung scintigraphy using technetium-99m-labeled albumin to measure pulmonary endothelial permeability.
  • Continuous pulmonary artery catheterization for hemodynamic monitoring.
  • Assay of serum inflammatory cytokines, including interleukin-8 and neutrophil elastase.

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Main Results:

  • Pulmonary endothelial permeability, measured by lung:heart radioactivity ratio, significantly increased post-pneumonectomy but not post-lobectomy.
  • Pulmonary artery pressure and vascular resistance increased during pneumonectomy.
  • Increased permeability correlated with elevated preoperative neutrophil elastase levels and perioperative pulmonary vascular resistance.

Conclusions:

  • Pulmonary endothelial permeability is elevated after pneumonectomy.
  • Preoperative neutrophil activation and pulmonary vasculature adaptation are potential causes.
  • Findings suggest mechanisms for postpneumonectomy pulmonary edema.