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New 1,2,6-thiadiazine dioxide acyclonucleosides: synthesis and antiviral evaluation
A I Esteban1, O Juanes, S Conde
1Instituto de Química Médica (CSIC), Madrid, Spain.
Bioorganic & Medicinal Chemistry
|November 1, 1995
Abstract:
New acyclonucleosides derived from 1,2,6-thiadiazine dioxide systems have been synthesized. Lipase-mediated deacylation procedure was used to obtain the deprotected derivatives. All the newly prepared compounds were tested as antiviral agents, but none of them showed significant activity.