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Two embryonal cancers after in vitro fertilization

A Toren1, N Sharon, M Mandel

  • 1Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

Cancer
|December 1, 1995
PubMed
Summary
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In vitro fertilization (IVF) is generally not linked to childhood cancers. However, this report details two rare pediatric tumors in children conceived via IVF, suggesting a potential association.

Area of Science:

  • Pediatric Oncology
  • Reproductive Medicine
  • Epidemiology

Background:

  • In vitro fertilization (IVF) is widely used globally.
  • Existing literature suggests no significant link between IVF and pediatric malignancies.
  • Only three cases of pediatric tumors in IVF-conceived children have been previously reported.

Observation:

  • Two cases of rare pediatric tumors are presented in children conceived via IVF.
  • The children, aged 12 and 18 months, were diagnosed with hepatoblastoma and clear cell sarcoma of the kidney, respectively.
  • Both pregnancies were uncomplicated, and no other risk factors were identified.

Findings:

  • One child with hepatoblastoma did not respond to chemotherapy (cisplatin, doxorubicin, vincristine).
  • The second child with kidney cancer is in remission after 18 months of treatment per the NWTS protocol.

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  • These cases add to the limited reported instances of pediatric malignancies in IVF-conceived children.

    • Implications:

    • The findings suggest a potential, though not definitively proven, association between IVF and pediatric cancers.
    • Further research is warranted to investigate this possible link and its underlying mechanisms.
    • This highlights the importance of continued surveillance and reporting of health outcomes in children conceived through assisted reproductive technologies.