Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Understanding the relationship between relative and absolute risk

W D Dupont1, W D Plummer

  • 1Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2637, USA.

Cancer
|June 1, 1996
PubMed
Summary

Absolute risk provides more valuable clinical decision-making information than relative risk. While relative risk approximations are useful for low risks, they fail for higher risks, necessitating accurate absolute risk estimation for patient care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased blood pressure visit-to-visit variability in patients with systemic lupus erythematosus: association with inflammation and comorbidity burden.

Lupus·2019
Same author

Analysis of factor VIII gene inversion mutations in 166 unrelated haemophilia A families: frequency and utility in genetic counselling.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

The diagnosis of adult-onset haemophagocytic lymphohistiocytosis: lessons learned from a review of 29 cases of bone marrow haemophagocytosis in two large academic institutions.

Journal of clinical pathology·2016
Same author

Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression.

Oncogene·2011
Same author

Immunohistochemical analysis of receptor tyrosine kinase signal transduction activity in chordoma.

Neuropathology and applied neurobiology·2007
Same author

Estimating the undetected burden of influenza hospitalizations in children.

Epidemiology and infection·2006

Area of Science:

  • Biostatistics
  • Clinical Decision-Making
  • Risk Assessment

Background:

  • Relative risks are commonly used to quantify outcomes but lack clinical decision-making value.
  • Absolute risks are more informative for patients and physicians.

Purpose of the Study:

  • To explain the relationship between relative and absolute risks.
  • To provide a method for estimating absolute risks from relative risks.

Main Methods:

  • Graphical aids illustrate the risk relationship.
  • An internet-accessible program utilizes a competing hazards model for estimation.
  • The program estimates absolute risks from relative risks.

Main Results:

  • Low absolute risks can be approximated by relative risk multiplied by reference population risk.

Related Experiment Videos

  • This approximation is inaccurate for higher absolute risks.
  • Risk relationships vary significantly across diseases, impacting estimate accuracy.

    • Conclusions:

    • Accurate absolute risk estimates are crucial for treatment decisions.
    • Reliable estimates can be derived from accurate relative risk data over 10-20 years.