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Sequential treatment of recurrent mesenteric desmoid tumor
T Bauernhofer1, H Stöger, M Schmid
1Department of Internal Medicine, Division of Oncology, Karl Franzens University, Graz, Austria.
Cancer
|March 15, 1996
Summary
This study details sequential treatment for an inoperable desmoid tumor. Combined goserelin acetate and tamoxifen therapy achieved long-term tumor regression and symptom relief.
Area of Science:
- Oncology
- Endocrinology
Background:
- Optimal management for inoperable desmoid tumors remains undefined.
- Presents a case of a recurrent intraabdominal desmoid tumor in a patient with familial adenomatous polyposis.
Observation:
- Sequential treatment involved various endocrine therapies and interferon gamma.
- Initial response observed with low-dose tamoxifen, followed by goserelin acetate plus low-dose tamoxifen.
Findings:
- Goserelin acetate combined with low-dose tamoxifen led to tumor size reduction and symptom relief for 17 months.
- Interferon gamma therapy subsequently halted tumor progression for an additional 6 months.
- High-dose tamoxifen and medroxyprogesterone acetate showed no significant effect.
Implications:
- Combined endocrine therapy with goserelin acetate and tamoxifen shows potential for long-term desmoid tumor regression.
- Interferon gamma offers a subsequent treatment option for managing tumor progression after initial endocrine therapy failure.